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CS-W001157 4
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4-Methylmorpholine hydrochloride

  • CAS No. 3651-67-0

  • Cat. No. CS-0151062
  • Molecule weight137.61
  • Purity≥98%
  • MDL No.MFCD00039042

*For research and further manufacturing use only, not for direct human use.

4-Methylmorpholine hydrochloride|CS-0151062

Structure of 3651-67-0

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General Information

  • CAS No. 3651-67-0
  • Cat. No. CS-0151062
  • Purity ≥98%
  • MDL No. MFCD00039042
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClNO
  • Molecular Weight 137.61
  • Synonym(s) N-Methylmorpholine hydrochloride
  • SMILES CN1CCOCC1.Cl

Description

4-Methylmorpholine hydrochloride is a bench-stable, moisture-tolerant amine salt that serves as a versatile catalyst and base in organic synthesis. Its protonated form enhances solubility in polar solvents, enabling efficient reaction kinetics. This compound integrates seamlessly into multistep transformations requiring mild basicity and low nucleophilicity, particularly in alkylation and acylation processes.

Application

4-Methylmorpholine hydrochloride serves as a versatile, bench-stable nitrogen source in synthetic organic chemistry. It functions as a nucleophilic catalyst and base in amide bond formation, esterifications, and alkylation reactions. Its high solubility and low volatility enhance handling safety and purification efficiency. The salt form ensures improved stability and reproducibility in standard laboratory workflows.

Synthesis

  • Route1
    • null|null
      816444-90-3
    • 3-AMINO-4-CYCLOBUTYL-2-OXOBUTANAMIDE HCL|CS-W000566
      817169-86-1
    • ~0%
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      Boceprevir|CS-0361
      394730-60-0
    • In-stock
      4-Methylmorpholine hydrochloride|CS-0151062
      3651-67-0

    References

    • SCHERING CORPORATION Patent: WO2004/113294 A1, 2004 ; Location in patent: Page/Page column 22-23 ;
  • Route2
    • null|null
      109-02-4
    • In-stock
      Chlorodimethoxytriazine|CS-W017434
      3140-73-6
    • (4S,5R)-2,4-Diphenyl-4,5-dihydrooxazole-5-carboxylic acid|CS-0210936
      158722-22-6
    • ~99%
    • In-stock
      4-Methylmorpholine hydrochloride|CS-0151062
      3651-67-0

    References

    • AGROPHARM S.A. Patent: WO2004/56790 A1, 2004 ; Location in patent: Page 12 ;
  • Route3

    References

    • Oiry, Joel; Puy, Jean-Yves; Imbach, Jean-Louis; Clayette, Pascal; Fretier, Philippe Patent: US2004/158092 A1, 2004 ; Location in patent: Page 12 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.47
  • LogP   0.3702
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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