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CS-W001157 4
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4-(3-bromophenethyl)morpholine

  • CAS No. 364793-86-2

  • Cat. No. CS-0160994
  • Molecule weight270.17
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(3-bromophenethyl)morpholine|CS-0160994

Structure of 364793-86-2

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General Information

  • CAS No. 364793-86-2
  • Cat. No. CS-0160994
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆BrNO
  • Molecular Weight 270.17
  • Synonym(s) 4-[2-(3-Bromophenyl)ethyl]morpholine
  • SMILES BrC1=CC(CCN2CCOCC2)=CC=C1

Description

4-(3-Bromophenethyl)morpholine features a morpholine ring tethered to a brominated phenethyl linker, delivering a versatile scaffold for medicinal chemistry. The para-bromo substitution enhances electrophilic reactivity in cross-coupling processes, while the morpholine moiety provides solubility and hydrogen-bonding capacity. This compound serves as a key intermediate in the synthesis of bioactive molecules, particularly in CNS-targeted drug discovery and kinase inhibitor development.

Application

4-(3-Bromophenethyl)morpholine serves as a versatile building block for medicinal chemistry and materials synthesis, enabling palladium-catalyzed cross-coupling reactions due to its stable aryl bromide functionality. The morpholine ring provides polarity and hydrogen-bonding capacity, enhancing solubility and modulating pharmacokinetic properties. Bench-stable and readily purified by column chromatography, it functions efficiently in standard coupling protocols and facilitates the construction of complex heterocyclic scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.47
  • LogP   2.3238
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   3

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