(1S,3S,5S)-3-(Aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester

Name: (1S,3S,5S)-3-(Aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 361440-67-7
Cat. No. CS-0030786
Purity≥97%
MDL No.MFCD13151933

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(1S,3S,5S)-3-(Aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester|CS-0030786

Structure of 361440-67-7

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 361440-67-7
Cat. No. CS-0030786
Purity ≥97%
MDL No. MFCD13151933
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₈N₂O₃
Molecular Weight 226.27
Synonym(s) Saxagliptin Intermediate
SMILES O=C(OC(C)(C)C)N1[C@]2(C[C@]2(C[C@H]1C(N)=O)[H])[H]

Description

This tert-butyl ester derivative features a rigid, stereochemically defined bicyclic scaffold with a pendant aminocarbonyl group. The (1S,3S,5S) configuration ensures precise spatial orientation for targeted interactions in synthetic and medicinal chemistry applications. Bench-stable and moisture-tolerant, it serves as a key building block for constrained peptidomimetics and bioactive heterocycles.

Application

(1S,3S,5S)-3-(Aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester serves as a conformationally constrained building block for medicinal chemistry campaigns targeting GPCR modulators and kinase inhibitors. Its rigid bicyclic core enables precise spatial orientation of the amide and ester functionalities, facilitating selective coupling reactions and improving metabolic stability in lead optimization. The tert-butyl ester group offers excellent bench stability and simplifies purification via standard acid-labile deprotection protocols.

Synthesis

Route1
- In-stock
  
  197142-36-2
- ~82%
- In-stock
  
  361440-67-7
References
- ALANTOS PHARMACEUTICALS, INC. Patent: WO2006/116157 A2, 2006 ; Location in patent: Page/Page column 114-116 ; WO 2006/116157 A2
Route2
- 709031-38-9
- 75-11-6
- ~53%
- In-stock
  
  361440-67-7
References
- Sharma, Padam N.; Galvin, Gabriel M.; Boettger, Susan D.; Racha, Saibaba; Zhu, Jingyang; Melton, Jack; Mudryk, Boguslaw M. Patent: US2006/35954 A1, 2006 ; Location in patent: Page/Page column 6-7 ;
Route3
- In-stock
  
  24424-99-5
- ~%
- In-stock
  
  361440-67-7
References
- Bioorganic and Medicinal Chemistry, , vol. 22, # 4 p. 1383 - 1393

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 72.63
LogP 0.8696
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Bridge Rings compounds Other bridge ring compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

361440-67-7 sigma361440-67-7 manufacturer361440-67-7 price361440-67-7 structure361440-67-7 SDSbuy 361440-67-7361440-67-7 supplier361440-67-7 uses361440-67-7 molecular weightprice of 361440-67-7361440-67-7 chemical name formula of 361440-67-7

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

(1S,3S,5S)-3-(Aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester

CAS No. 361440-67-7

Recommended Products

General Information

Description

Application

Synthesis

References

References

References

Safety Information

Quality Control

Computational Chemistry Data

Similar Products

Other Classifications

Recently Viewed Products

Key Words