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CS-W001157 4
Total: USD 88.00

5-Bromo-2-methylphenol

  • CAS No. 36138-76-8

  • Cat. No. CS-W008161
  • Purity≥97%
  • MDL No.MFCD08061906

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-methylphenol|CS-W008161

Structure of 36138-76-8

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General Information

  • CAS No. 36138-76-8
  • Cat. No. CS-W008161
  • Purity ≥97%
  • MDL No. MFCD08061906
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BrO
  • Molecular Weight 187.03
  • Synonym(s) Phenol,5-bromo-2-methyl-; 5-Bromo-2-methylphenol
  • SMILES BrC1=CC(=C(C=C1)C)O

Description

5-Bromo-2-methylphenol features a bromine atom at the para position relative to a methyl-substituted phenolic hydroxyl group. This electron-deficient aromatic scaffold enables direct functionalization in cross-coupling reactions and serves as a key intermediate in pharmaceutical synthesis.

Application

5-Bromo-2-methylphenol serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of substituted heterocycles and pharmaceutical intermediates. Its ortho-methyl and bromo substituents provide complementary reactivity for Suzuki-Miyaura coupling and electrophilic aromatic substitution, while the phenolic hydroxyl group offers direct functionalization potential. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      2835-95-2
    • ~26%
    • In-stock
      5-Bromo-2-methylphenol|CS-W008161
      36138-76-8

    References

    • AMEDIS PHARMACEUTICALS LTD. Patent: WO2005/5442 A1, 2005 ; Location in patent: Page 22; 28 ;
  • Route2
    • null|null
      95-48-7
    • ~%
    • In-stock
      3-Bromo-2-methylphenol|CS-W005698
      7766-23-6
    • In-stock
      5-Bromo-2-methylphenol|CS-W008161
      36138-76-8

    References

    • Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 32 - 41
  • Route3
    • null|null
      7647-01-0
    • null|null
      5532-69-4
    • ~%
    • In-stock
      5-Bromo-2-methylphenol|CS-W008161
      36138-76-8
    • In-stock
      4-Bromo-2-(hydroxymethyl)phenol|CS-W015481
      2316-64-5

    References

    • Justus Liebigs Annalen der Chemie, , vol. 302, p. 145

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.46312
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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