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CS-W001157 4
Total: USD 88.00

tert-Butyl (1-(4-bromophenyl)cyclopropyl)carbamate

  • CAS No. 360773-84-8

  • Cat. No. CS-0041042
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (1-(4-bromophenyl)cyclopropyl)carbamate|CS-0041042

Structure of 360773-84-8

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General Information

  • CAS No. 360773-84-8
  • Cat. No. CS-0041042
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₈BrNO₂
  • Molecular Weight 312.20
  • Synonym(s) t-Butyl 1-(4-bromophenyl)cyclopropylcarbamate
  • SMILES O=C(OC(C)(C)C)NC1(C2=CC=C(Br)C=C2)CC1

Description

tert-Butyl (1-(4-bromophenyl)cyclopropyl)carbamate features a cyclopropyl scaffold bearing a para-bromophenyl group and a tert-butyl carbamate protecting group. This stable, bench-ready building block integrates readily into synthetic sequences requiring aryl-cyclopropyl linkages. The bromine handle enables downstream cross-coupling transformations, while the carbamate moiety offers convenient deprotection under mild acidic conditions.

Application

tert-Butyl (1-(4-bromophenyl)cyclopropyl)carbamate serves as a stable, bench-ready building block for the synthesis of cyclopropyl-containing pharmaceutical intermediates. The carbamate group enables mild deprotection under acidic conditions, while the pendant 4-bromophenyl moiety supports palladium-catalyzed cross-coupling reactions. Its robustness and compatibility with standard synthetic workflows make it ideal for constructing complex heterocyclic and biaryl architectures in medicinal chemistry.

Synthesis

  • Route1

    References

    • ArQule, Inc. Patent: US2012/108574 A1, 2012 ; Location in patent: Page/Page column 113 ;
  • Route2
    • In-stock
      1-(4-Bromophenyl)cyclopropanecarboxylic acid|CS-W020617
      345965-52-8
    • null|null
      75-65-0
    • ~64%
    • In-stock
      tert-Butyl (1-(4-bromophenyl)cyclopropyl)carbamate|CS-0041042
      360773-84-8

    References

    • Allergan Sales, Inc. Patent: US6369225 B1, 2002 ; Location in patent: Page column 42, 112 ;
  • Route3

    References

    • BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG Patent: WO2005/63239 A1, 2005 ; Location in patent: Page/Page column 129 ; WO 2005/063239 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   3.9629
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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