4-(4-Fluorobenzylamino)-1-methylpiperidine

Name: 4-(4-Fluorobenzylamino)-1-methylpiperidine
Brand: ChemScene
Availability: InStock
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CAS No. 359878-47-0
Cat. No. CS-M3670
Purity≥96%
MDL No.MFCD00979813

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-(4-Fluorobenzylamino)-1-methylpiperidine|CS-M3670

Structure of 359878-47-0

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General Information

CAS No. 359878-47-0
Cat. No. CS-M3670
Purity ≥96%
MDL No. MFCD00979813
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₉FN₂
Molecular Weight 222.30
Synonym(s) N-[(4-Fluorophenyl)methyl]-1-methyl-4-piperidinamine; (4-Fluoro-benzyl)-(1-methyl-piperidin-4-yl)-amine
SMILES CN1CCC(NCC2=CC=C(F)C=C2)CC1

Description

4-(4-Fluorobenzylamino)-1-methylpiperidine features a fluorinated aromatic linker that enhances metabolic stability and membrane permeability. The piperidine core provides a basic nitrogen for salt formation and pharmacophore integration, while the methyl group at the 1-position modulates electronic properties and steric profile. This scaffold is well-suited for medicinal chemistry campaigns targeting CNS receptors and kinase pathways.

Application

4-(4-Fluorobenzylamino)-1-methylpiperidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard amine coupling and functional group interconversions. Its fluorinated aryl moiety enhances metabolic stability and membrane permeability, while the piperidine core provides a basic nitrogen for salt formation and target engagement. The compound exhibits excellent bench stability, ease of purification, and compatibility with common reaction conditions, facilitating integration into multi-step syntheses of CNS-targeted therapeutics and kinase inhibitors.

Synthesis

Route1
- 1445-73-4
- In-stock
  
  140-75-0
- ~91%
- In-stock
  
  359878-47-0
References
- AUSPEX PHARMACEUTICALS, INC. Patent: US2008/280886 A1, 2008 ; Location in patent: Page/Page column 21 ; US 20080280886 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 15.27
LogP 2.0095
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-(4-Fluorobenzylamino)-1-methylpiperidine

CAS No. 359878-47-0

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