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(S)-2-(3-Fluorophenyl)pyrrolidine hydrochloride

  • CAS No. 1360442-16-5

  • Cat. No. CS-0138162
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-2-(3-Fluorophenyl)pyrrolidine hydrochloride|CS-0138162

Structure of 1360442-16-5

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General Information

  • CAS No. 1360442-16-5
  • Cat. No. CS-0138162
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃ClFN
  • Molecular Weight 201.67
  • Synonym(s) (S)-2-(3-fluorophenyl)pyrrolidine HCl
  • SMILES FC1=CC([C@H]2NCCC2)=CC=C1.[H]Cl

Description

This chiral pyrrolidine derivative features a 3-fluorophenyl group attached to the 2-position, delivering enhanced metabolic stability and improved binding affinity in target-directed synthesis. The hydrochloride salt form ensures excellent solubility and crystalline purity, enabling reliable use in medicinal chemistry campaigns requiring stereocontrolled building blocks.

Application

(S)-2-(3-Fluorophenyl)pyrrolidine hydrochloride serves as a versatile chiral building block in medicinal chemistry, enabling the synthesis of bioactive molecules through established coupling and functionalization reactions. The pyrrolidine core provides structural rigidity and favorable pharmacokinetic properties, while the 3-fluorophenyl group enhances metabolic stability and modulates electronic effects. Bench-stable and readily purified, it functions effectively in standard amine-based transformations, including reductive amination, acylation, and transition-metal-catalyzed cross-coupling, supporting efficient route development for API candidates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.672
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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