2-Morpholinopyridin-4-amine

Name: 2-Morpholinopyridin-4-amine
Brand: ChemScene
Availability: InStock
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CAS No. 35980-77-9
Cat. No. CS-W021731
Purity≥98%
MDL No.MFCD02945666

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 35980-77-9

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Description

2-Morpholinopyridin-4-amine features a pyridine core functionalized with a morpholine ring and a primary amine at the 4-position, enabling dual-site reactivity. This combination delivers enhanced solubility and tunable basicity, making it valuable for medicinal chemistry applications. The molecule integrates readily into kinase inhibitors and catalytic scaffolds due to its ability to engage in hydrogen bonding and coordinate metal centers.

Application

2-Morpholinopyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to kinase inhibitors and other bioactive heterocycles. Its pyridine core provides a strong hydrogen bond acceptor site, while the morpholine ring enhances solubility and metabolic stability. The amine functionality facilitates straightforward derivatization via coupling reactions, and the molecule exhibits good bench stability and ease of purification—key attributes for scalable synthesis and high-throughput screening workflows.

General Information

CAS No. 35980-77-9
Cat. No. CS-W021731
Purity ≥98%
MDL No. MFCD02945666
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₃N₃O
Molecular Weight 179.22
Synonym(s) 2-(4-morpholinyl)-4-pyridinylamine
SMILES NC1=CC(=NC=C1)N1CCOCC1

Computational Chemistry Data

TPSA 51.38
LogP 0.5004
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Morpholine compounds

Key Words

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2-Morpholinopyridin-4-amine

CAS No. 35980-77-9

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