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CS-W001157 4
Total: USD 88.00

2-Bromonicotinic acid

  • CAS No. 35905-85-2

  • Cat. No. CS-D0803
  • Purity≥97%
  • MDL No.MFCD01646068

*For research and further manufacturing use only, not for direct human use.

2-Bromonicotinic acid|CS-D0803

Structure of 35905-85-2

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General Information

  • CAS No. 35905-85-2
  • Cat. No. CS-D0803
  • Purity ≥97%
  • MDL No. MFCD01646068
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrNO₂
  • Molecular Weight 202.01
  • Synonym(s) Akos Bbs-00001340
  • SMILES O=C(O)C1=C(Br)N=CC=C1

Description

5-HT receptor antagonist; partial agonist at adrenergic and dopaminergic receptors

Application

2-Bromonicotinic acid serves as a versatile building block in heterocyclic synthesis, enabling direct functionalization at the pyridine ring's C2 position. Its bromine substituent facilitates palladium-catalyzed cross-coupling reactions, including Suzuki-Miyaura and Stille couplings, with high efficiency and selectivity. The carboxylic acid group supports derivatization via esterification or amide formation, enhancing its utility in medicinal chemistry and materials science applications. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for routine laboratory use.

Synthesis

  • Route1

    References

    • Spivey, Alan C.; Shukla, Lena; Hayler, Judy F. Organic Letters, 2007 , vol. 9, # 5 p. 891 - 894
  • Route2

    References

    • Wang; Snieckus Tetrahedron Letters, 1991 , vol. 32, # 37 p. 4883 - 4884
  • Route3
    • null|null
      109-04-6
    • ~%
    • In-stock
      2-Bromonicotinic acid|CS-D0803
      35905-85-2

    References

    • Synthetic Communications, , vol. 23, # 19 p. 2727 - 2730

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.5423
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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