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CS-W001157 4
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Methyl 2-bromonicotinate

  • CAS No. 52718-95-3

  • Cat. No. CS-0096861
  • Purity≥97%
  • MDL No.MFCD07367915

*For research and further manufacturing use only, not for direct human use.

Methyl 2-bromonicotinate|CS-0096861

Structure of 52718-95-3

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General Information

  • CAS No. 52718-95-3
  • Cat. No. CS-0096861
  • Purity ≥97%
  • MDL No. MFCD07367915
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrNO₂
  • Molecular Weight 216.03
  • Synonym(s) Methyl 2-Bromopyridine-3-carboxylate
  • SMILES O=C(C1=CC=CN=C1Br)OC

Description

Methyl 2-bromonicotinate is a bench-stable, moisture-tolerant brominated pyridine derivative featuring a strategically positioned ester group. This compound integrates readily into cross-coupling reactions and serves as a key intermediate for synthesizing bioactive heterocycles and functionalized pharmaceuticals.

Application

Methyl 2-bromonicotinate serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization at the pyridine ring via palladium-catalyzed cross-coupling reactions. Its bromo group exhibits high reactivity in Suzuki, Stille, and Negishi couplings, while the methyl ester facilitates selective derivatization. The compound demonstrates excellent bench stability and compatibility with diverse reaction conditions, making it ideal for constructing complex heterocyclic scaffolds and pharmaceutical intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.6307
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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