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CS-W001157 4
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2-Pyridone-6-carboxaldehyde

  • CAS No. 358751-77-6

  • Cat. No. CS-0046233
  • Purity≥95%
  • MDL No.MFCD10688270

*For research and further manufacturing use only, not for direct human use.

2-Pyridone-6-carboxaldehyde|CS-0046233

Structure of 358751-77-6

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General Information

  • CAS No. 358751-77-6
  • Cat. No. CS-0046233
  • Purity ≥95%
  • MDL No. MFCD10688270
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅NO₂
  • Molecular Weight 123.11
  • Synonym(s) 6-Oxo-1,6-dihydropyridine-2-carbaldehyde
  • SMILES O=CC1=CC=CC(=O)N1

Description

2-Pyridone-6-carboxaldehyde features a conjugated system linking a pyridone ring with an aldehyde functional group, enabling direct participation in nucleophilic addition and condensation reactions. This scaffold supports efficient integration into bioactive heterocycles and molecular scaffolds requiring controlled reactivity under mild conditions.

Application

2-Pyridone-6-carboxaldehyde serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized heterocycles and bioactive scaffolds. Its dual functionality—carboxaldehyde and lactam—facilitates selective derivatization, including reductive amination and nucleophilic addition reactions. The compound exhibits good bench stability and compatibility with common protecting group strategies, making it well-suited for modular synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1
    • 6-(Hydroxymethyl)pyridin-2-ol|CS-0247901
      352514-21-7
    • ~21%
    • In-stock
      2-Pyridone-6-carboxaldehyde|CS-0046233
      358751-77-6

    References

    • US2006/19965 A1, ; Page/Page column 27 ; US 20060019965 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.93
  • LogP   0.1874
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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