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CS-W001157 4
Total: USD 88.00

2-Methylthiazole

  • CAS No. 3581-87-1

  • Cat. No. CS-W002260
  • Purity≥98%
  • MDL No.MFCD00053144

*For research and further manufacturing use only, not for direct human use.

2-Methylthiazole|CS-W002260

Structure of 3581-87-1

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General Information

  • CAS No. 3581-87-1
  • Cat. No. CS-W002260
  • Purity ≥98%
  • MDL No. MFCD00053144
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅NS
  • Molecular Weight 99.15
  • Synonym(s) 2-methyl-1,3-thiazole; 2-Methylthiazole
  • SMILES CC1=NC=CS1

Description

2-Methylthiazole is a heterocyclic compound featuring a thiazole ring with a methyl group at the 2-position. This electron-rich scaffold exhibits enhanced solubility in organic solvents and serves as a key structural motif in medicinal chemistry. The molecule integrates readily into bioactive frameworks, offering favorable metabolic stability and compatibility with diverse synthetic transformations.

Application

2-Methylthiazole serves as a versatile heterocyclic building block in medicinal chemistry and materials science, enabling efficient access to thiazole-based scaffolds. Its methyl substituent enhances stability and facilitates electrophilic functionalization, while the nitrogen-sulfur core supports diverse coupling reactions and metal-catalyzed transformations. The compound exhibits good bench stability and is compatible with standard purification techniques, making it a practical choice for synthetic workflows targeting bioactive molecules and advanced functional materials.

Synthesis

  • Route1

    References

    • Jaber, Nimer; Schumann, Herbert; Blum, Jochanan Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 4 p. 565 - 567
  • Route2
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      15873-56-0
    • In-stock
      Thioacetamide|CS-W018499
      62-55-5
    • ~%
    • In-stock
      2-Methylthiazole|CS-W002260
      3581-87-1

    References

    • Journal of the American Chemical Society, , vol. 74, p. 5778 Helvetica Chimica Acta, , vol. 31, p. 1142,1156
  • Route3

    References

    • US2870158 , ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Warning
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.45152
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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