Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-Cyanothiazole

  • CAS No. 1452-16-0

  • Cat. No. CS-W003625
  • Purity≥98%
  • MDL No.MFCD09702472

*For research and further manufacturing use only, not for direct human use.

2-Cyanothiazole|CS-W003625

Structure of 1452-16-0

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 1452-16-0
  • Cat. No. CS-W003625
  • Purity ≥98%
  • MDL No. MFCD09702472
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂N₂S
  • Molecular Weight 110.14
  • Synonym(s) None
  • SMILES N#CC1=NC=CS1

Description

2-Cyanothiazole serves as a pivotal heterocyclic scaffold in medicinal chemistry, integrating a nitrile group directly adjacent to a thiazole ring. This arrangement imparts enhanced polarity and metabolic stability, enabling efficient incorporation into bioactive molecules. The electron-deficient nature of the ring facilitates targeted covalent interactions, while the bench-stable structure supports straightforward handling in synthetic workflows.

Application

2-Cyanothiazole serves as a versatile heterocyclic building block in synthetic organic chemistry, enabling efficient access to thiazole-based scaffolds through electrophilic substitution and transition-metal-catalyzed coupling reactions. Its nitrile group enhances functional group tolerance and provides a handle for downstream derivatization, while the ring exhibits robust bench stability and compatibility with standard purification methods. This compound functions effectively in the construction of medicinally relevant heterocycles and advanced intermediates for pharmaceutical development.

Synthesis

  • Route1

    References

    • EP1555257 A1, ; Page/Page column 25 ;
  • Route2
    • 1,3-Thiazole-2-carbaldehyde oxime|CS-0770489
      13838-77-2
    • ~%
    • In-stock
      2-Cyanothiazole|CS-W003625
      1452-16-0

    References

    • Journal of Medicinal Chemistry, , vol. 55, # 1 p. 68 - 83
  • Route3
    • null|null
      19158-51-1
    • In-stock
      2-(Trimethylsilyl)thiazole|CS-W010908
      79265-30-8
    • ~72%
    • In-stock
      2-Cyanothiazole|CS-W003625
      1452-16-0

    References

    • Nagasaki, Izuru; Suzuki, Yumiko; Iwamoto, Ken-Ichi; Higashino, Takeo; Miyashita, Akira Heterocycles, 1997 , vol. 46, # 1 p. 443 - 450

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 3439
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302+H332-H311-H315-H319-H335-H373
Precautionary Statements : P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P361+P364-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.01478
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2-Cyanothiazole sigma2-Cyanothiazole manufacturer2-Cyanothiazole price2-Cyanothiazole structure2-Cyanothiazole SDSbuy 2-Cyanothiazole2-Cyanothiazole supplier2-Cyanothiazole uses2-Cyanothiazole molecular weightprice of 2-Cyanothiazole2-Cyanothiazole chemical name formula of 2-Cyanothiazole
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label