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CS-W001157 4
Total: USD 88.00

Trimethoxy(4-methoxyphenyl)silane

  • CAS No. 35692-27-4

  • Cat. No. CS-0213688
  • Molecule weight228.32
  • Purity≥96%
  • MDL No.MFCD01861721

*For research and further manufacturing use only, not for direct human use.

Trimethoxy(4-methoxyphenyl)silane|CS-0213688

Structure of 35692-27-4

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General Information

  • CAS No. 35692-27-4
  • Cat. No. CS-0213688
  • Purity ≥96%
  • MDL No. MFCD01861721
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₆O₄Si
  • Molecular Weight 228.32
  • Synonym(s) P-methoxyphenyltrimethoxysilane
  • SMILES CO[Si](C1=CC=C(OC)C=C1)(OC)OC

Description

Trimethoxy(4-methoxyphenyl)silane features a para-methoxy-substituted phenyl group attached to a silicon center bearing three methoxy ligands. This configuration imparts enhanced hydrolytic stability and improved solubility in organic solvents, facilitating its use in sol-gel processes and surface functionalization. The electron-donating methoxy group modulates reactivity, enabling controlled condensation kinetics for precise material deposition.

Application

Trimethoxy(4-methoxyphenyl)silane serves as a stable, bench-ready silylating agent that facilitates efficient protection of alcohols and amines in complex molecule synthesis. Its ortho-silyl group enables selective functionalization and orthogonal deprotection under mild conditions. The 4-methoxyphenyl moiety enhances solubility and stability while providing a convenient handle for downstream derivatization. This reagent functions reliably in standard coupling and cross-coupling workflows.

Synthesis

  • Route1
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      2487-90-3
    • In-stock
      4-Iodoanisole|CS-W003965
      696-62-8
    • ~%
    • In-stock
      Trimethoxy(4-methoxyphenyl)silane|CS-0213688
      35692-27-4

    References

    • Journal of the American Chemical Society, , vol. 122, # 31 p. 7600 - 7601
  • Route2
    • null|null
      67-56-1
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      705-34-0
    • ~%
    • In-stock
      Trimethoxy(4-methoxyphenyl)silane|CS-0213688
      35692-27-4

    References

    • Chemical Communications, , # 14 p. 1309 - 1310

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   36.92
  • LogP   0.7803
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   5

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