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CS-W001157 4
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3-Chloropropane-1-sulfonamide

  • CAS No. 35578-28-0

  • Cat. No. CS-0145618
  • Purity≥97%
  • MDL No.MFCD12107254

*For research and further manufacturing use only, not for direct human use.

3-Chloropropane-1-sulfonamide|CS-0145618

Structure of 35578-28-0

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General Information

  • CAS No. 35578-28-0
  • Cat. No. CS-0145618
  • Purity ≥97%
  • MDL No. MFCD12107254
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₈ClNO₂S
  • Molecular Weight 157.62
  • Synonym(s) None
  • SMILES O=S(CCCCl)(N)=O

Description

3-Chloropropane-1-sulfonamide is a bench-stable sulfonamide derivative featuring a chlorine-substituted propyl chain. This compound integrates a reactive chloro group with a sulfonamide functionality, enabling direct coupling in synthetic transformations. The para-positioned sulfonamide enhances solubility and stability, supporting efficient incorporation into bioactive scaffolds and pharmaceutical intermediates under standard conditions.

Application

3-Chloropropane-1-sulfonamide serves as a versatile sulfonamide building block in medicinal chemistry, enabling the construction of bioactive heterocycles and peptide mimetics. Its chloroalkyl side chain facilitates nucleophilic substitution reactions, while the sulfonamide group provides strong hydrogen bonding capacity and metabolic stability. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • null|null
      1633-82-5
    • ~97%
    • In-stock
      3-Chloropropane-1-sulfonamide|CS-0145618
      35578-28-0

    References

    • Tsuri; Haga; Matsui; Kamata; Kakushi; Uchida Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 1 p. 75 - 84
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    References

    • Troyanskii, E. I.; Lazareva, M. I.; Nikishin, G. I. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1986 , vol. 35, p. 1428 - 1434 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1986 , # 7 p. 1575 - 1582
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    References

    • Helberger,J.H.; Sproviero,J.F. Justus Liebigs Annalen der Chemie, 1963 , vol. 666, p. 67 - 74

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   60.16
  • LogP   -0.0962
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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