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CS-W001157 4
Total: USD 88.00

2-Amino-3,5-dibromopyridine

  • CAS No. 35486-42-1

  • Cat. No. CS-W002171
  • Purity≥96%
  • MDL No.MFCD00038041

*For research and further manufacturing use only, not for direct human use.

2-Amino-3,5-dibromopyridine|CS-W002171

Structure of 35486-42-1

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General Information

  • CAS No. 35486-42-1
  • Cat. No. CS-W002171
  • Purity ≥96%
  • MDL No. MFCD00038041
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄Br₂N₂
  • Molecular Weight 251.91
  • Synonym(s) Maybridge1_001693
  • SMILES BrC(C=N1)=CC(Br)=C1N

Description

2-Amino-3,5-dibromopyridine features a pyridine core substituted with amino and bromine groups at the 2 and 3,5 positions, respectively. This electron-deficient heterocycle serves as a key building block in the synthesis of functionalized pharmaceutical intermediates and advanced materials. The presence of two bromine atoms enables efficient cross-coupling reactions, while the amino group offers a handle for further derivatization under mild conditions. The compound exhibits good stability under standard handling protocols.

Application

2-Amino-3,5-dibromopyridine serves as a versatile building block for the synthesis of brominated heterocycles and pharmaceutical intermediates. Its dual bromo groups enable palladium-catalyzed cross-coupling reactions, while the amino functionality offers site-specific derivatization. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      504-29-0
    • ~95%
    • In-stock
      2-Amino-3,5-dibromopyridine|CS-W002171
      35486-42-1

    References

    • Majumdar; Mondal Tetrahedron Letters, 2007 , vol. 48, # 39 p. 6951 - 6953
  • Route2
    • null|null
      504-29-0
    • ~2%
    • In-stock
      2-Amino-5-bromopyridine|CS-D1666
      1072-97-5
    • In-stock
      2-Amino-3,5-dibromopyridine|CS-W002171
      35486-42-1

    References

    • Synthetic Communications, , vol. 16, # 13 p. 1641 - 1646
  • Route3
    • null|null
      148292-03-9
    • ~70%
    • In-stock
      2-Amino-3,5-dibromopyridine|CS-W002171
      35486-42-1

    References

    • Burgos; Delgado; Garcia-Navio; Izquierdo; Alvarez-Builla Tetrahedron, 1995 , vol. 51, # 31 p. 8649 - 8654

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.1888
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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