Dimethylsulfamoyl fluoride

Name: Dimethylsulfamoyl fluoride
Brand: ChemScene
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CAS No. 354-44-9
Cat. No. CS-0526924
Purity≥98%
MDL No.MFCD01683123

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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General Information

CAS No. 354-44-9
Cat. No. CS-0526924
Purity ≥98%
MDL No. MFCD01683123
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂H₆FNO₂S
Molecular Weight 127.14
Synonym(s) Sulfamyl fluoride,N,N-dimethyl
SMILES O=S(N(C)C)(F)=O

Description

Dimethylsulfamoyl fluoride delivers a highly reactive sulfamoyl fluorine moiety, enabling efficient incorporation into diverse molecular architectures. This bench-stable reagent features exceptional electrophilicity at sulfur, facilitating direct fluorination and sulfonylation reactions under mild conditions. Its moisture-tolerant profile enhances handling convenience in synthetic workflows.

Application

Dimethylsulfamoyl fluoride serves as a versatile sulfamoylation reagent, enabling direct introduction of the sulfonylamine (SO₂NMe₂) group under mild conditions. It exhibits high reactivity toward nucleophiles such as alcohols and amines, facilitating efficient synthesis of sulfamoyl derivatives with excellent functional group tolerance. The reagent demonstrates bench stability and ease of handling, making it suitable for scalable transformations in medicinal chemistry and agrochemical synthesis.

Synthesis

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References
- I.G. Farbenind. Patent: FR806383 ; Full Text Show Details I.G. Farbenind. Patent: DE667544 , 1935 ; Full Text Show Details Winthrop Chem. Co. Patent: US2130038 , 1936 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 25, p. 1347
Route2
- 63698-79-3
- ~%
- In-stock
  
  354-44-9
References
- Appel,R.; Montenarh,M. Chemische Berichte, 1977 , vol. 110, p. 2368 - 2373

Safety Information

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GHS Pictogram :	GHS No : GHS02,GHS05,GHS06
Signal Word : Danger	UN#: 3286
Class : 3(6.1,8)	Packing Group : Ⅱ
Hazard Statements : H225-H301-H314-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P280-P301+P330+P331-P304+P340-P330-P363-P370+P378-P405-P501

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Computational Chemistry Data

TPSA 37.38
LogP -0.2377
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Sulfonamide

Material Science Electronic Materials Battery Materials Organic Solvents

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Dimethylsulfamoyl fluoride

CAS No. 354-44-9

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