6-Chloro-5-iodopyrimidin-4-amine

Name: 6-Chloro-5-iodopyrimidin-4-amine
Brand: ChemScene
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CAS No. 353272-15-8
Cat. No. CS-0054923
Molecule weight255.44
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Chloro-5-iodopyrimidin-4-amine|CS-0054923

Structure of 353272-15-8

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General Information

CAS No. 353272-15-8
Cat. No. CS-0054923
Purity ≥97%
MDL No. None
Storage -20°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₃ClIN₃
Molecular Weight 255.44
Synonym(s) None
SMILES NC1=NC=NC(Cl)=C1I

Description

6-Chloro-5-iodopyrimidin-4-amine features a dual halogenated pyrimidine core, enabling selective cross-coupling reactions in medicinal chemistry. The chloro group at C6 and iodo substituent at C5 offer orthogonal reactivity for sequential functionalization. This scaffold integrates readily into bioactive molecules, particularly in kinase inhibitors and nucleoside analogs.

Application

6-Chloro-5-iodopyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The chlorine and iodine substituents allow sequential functionalization, while the pyrimidine amine group facilitates derivatization via amidation or alkylation. This compound exhibits good bench stability and is compatible with standard reaction conditions, making it ideal for constructing heterocyclic scaffolds in API development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 51.8
LogP 1.3168
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Iodide

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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6-Chloro-5-iodopyrimidin-4-amine

CAS No. 353272-15-8

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