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Structure of 353272-15-8
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6-Chloro-5-iodopyrimidin-4-amine features a dual halogenated pyrimidine core, enabling selective cross-coupling reactions in medicinal chemistry. The chloro group at C6 and iodo substituent at C5 offer orthogonal reactivity for sequential functionalization. This scaffold integrates readily into bioactive molecules, particularly in kinase inhibitors and nucleoside analogs.
6-Chloro-5-iodopyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The chlorine and iodine substituents allow sequential functionalization, while the pyrimidine amine group facilitates derivatization via amidation or alkylation. This compound exhibits good bench stability and is compatible with standard reaction conditions, making it ideal for constructing heterocyclic scaffolds in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: