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CS-W001157 4
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(5-Formyl-4-methylthiophen-2-yl)boronic acid

  • CAS No. 352530-25-7

  • Cat. No. CS-0109660
  • Purity≥98%
  • MDL No.MFCD03093890

*For research and further manufacturing use only, not for direct human use.

(5-Formyl-4-methylthiophen-2-yl)boronic acid|CS-0109660

Structure of 352530-25-7

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General Information

  • CAS No. 352530-25-7
  • Cat. No. CS-0109660
  • Purity ≥98%
  • MDL No. MFCD03093890
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BO₃S
  • Molecular Weight 169.99
  • Synonym(s) 5-Formyl-4-Methylthiophene-2-Boronic Acid
  • SMILES OB(C1=CC(C)=C(C=O)S1)O

Description

This boronate moiety integrates a formyl group and methylthio substituent on a thiophene scaffold, enabling direct functionalization in cross-coupling reactions. The electron-deficient thiophene ring enhances reactivity, while the pendant aldehyde offers downstream derivatization potential. Bench-stable under standard conditions, this reagent streamlines access to complex heterocyclic architectures.

Application

(5-Formyl-4-methylthiophen-2-yl)boronic acid serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. Its formyl group offers orthogonal reactivity for downstream functionalization, while the boronic acid moiety ensures excellent stability and compatibility with standard Suzuki-Miyaura coupling conditions. The methylthio substituent enhances solubility and facilitates purification, making this reagent well-suited for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   -0.45118
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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