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CS-W001157 4
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3-Chlorocyclobutane-1-carboxylic acid

  • CAS No. 35207-71-7

  • Cat. No. CS-0051401
  • Molecule weight134.56
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Chlorocyclobutane-1-carboxylic acid|CS-0051401

Structure of 35207-71-7

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General Information

  • CAS No. 35207-71-7
  • Cat. No. CS-0051401
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇ClO₂
  • Molecular Weight 134.56
  • Synonym(s) 3-Chlorocyclobutanecarboxylic acid
  • SMILES OC(=O)C1CC(Cl)C1

Description

3-Chlorocyclobutane-1-carboxylic acid features a strained cyclobutane ring with a chlorine atom at the 3-position and a carboxylic acid group at C1. This configuration imparts enhanced reactivity for functionalization and enables integration into bioactive scaffolds requiring constrained geometries. The molecule exhibits good stability under standard bench conditions and serves as a key building block in medicinal chemistry and synthetic methodology development.

Application

3-Chlorocyclobutane-1-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of constrained cyclobutane scaffolds with defined stereochemistry. The carboxylic acid group facilitates direct derivatization or coupling reactions, while the adjacent chloro substituent offers a handle for nucleophilic substitution or transition-metal-catalyzed transformations. Its bench-stable nature and compatibility with standard protecting group strategies make it well-suited for multi-step synthesis and process development workflows.

Synthesis

  • Route1

    References

    • Tetrahedron Letters, , vol. 30, # 50 p. 6955 - 6958
  • Route2
    • 3-Chlorocyclobutane-1,1-dicarboxylic acid|CS-0051402
      89639-43-0
    • ~65%
    • In-stock
      3-Chlorocyclobutane-1-carboxylic acid|CS-0051401
      35207-71-7

    References

    • Radchenko, Dmytro S.; Tkachenko, Anton; Grygorenko, Oleksandr O.; Komarov, Igor V. Synthetic Communications, 2011 , vol. 41, # 11 p. 1644 - 1649
  • Route3
    • 3-Chlorocyclobutane-1-carbonitrile|CS-0056255
      20249-18-7
    • ~%
    • In-stock
      3-Chlorocyclobutane-1-carboxylic acid|CS-0051401
      35207-71-7

    References

    • Journal of the American Chemical Society, , vol. 93, p. 121 - 130

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.0884
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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