Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

3-Fluorocyclobutanecarboxylic acid

  • CAS No. 122665-96-7

  • Cat. No. CS-0036337
  • Purity≥97%
  • MDL No.MFCD09834117

*For research and further manufacturing use only, not for direct human use.

3-Fluorocyclobutanecarboxylic acid|CS-0036337

Structure of 122665-96-7

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 122665-96-7
  • Cat. No. CS-0036337
  • Purity ≥97%
  • MDL No. MFCD09834117
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇FO₂
  • Molecular Weight 118.11
  • Synonym(s) cyclobutanecarboxylic acid, 3-fluoro-
  • SMILES C1C(CC1F)C(=O)O

Description

3-Fluorocyclobutanecarboxylic acid features a strained cyclobutane ring with a fluorine atom at the 3-position, enhancing its metabolic stability and electronic properties. This configuration imparts unique conformational rigidity, enabling precise spatial control in medicinal chemistry applications. The carboxylic acid group facilitates direct derivatization or salt formation for improved solubility and handling.

Application

3-Fluorocyclobutanecarboxylic acid serves as a valuable building block in medicinal chemistry, offering a rigid, bioisosteric replacement for cyclopropyl or cyclohexyl moieties. Its fluorinated cyclobutane core enhances metabolic stability and modulates lipophilicity, while the carboxylic acid functionality enables direct derivatization via amide formation, esterification, or coupling reactions. The compound exhibits good bench stability and is compatible with standard purification methods, facilitating integration into diverse synthetic sequences for targeted scaffold development.

Synthesis

  • Route1
    • 3-Fluorocyclobutane-1,1-dicarboxylic acid|CS-0057136
      123812-77-1
    • ~80%
    • In-stock
      3-Fluorocyclobutanecarboxylic acid|CS-0036337
      122665-96-7

    References

    • Dolbier; Gray; Keaffaber; Celewicz; Koronia k Journal of the American Chemical Society, 1990 , vol. 112, # 1 p. 363 - 367
  • Route2
    • Diethyl 3-fluorocyclobutane-1,1-dicarboxylate|CS-0141574
      123812-76-0
    • ~%
    • In-stock
      3-Fluorocyclobutanecarboxylic acid|CS-0036337
      122665-96-7

    References

    • Journal of the American Chemical Society, , vol. 112, # 1 p. 363 - 367

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   37.3
  • LogP   0.8191
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 3-Fluorocyclobutanecarboxylic acid sigma3-Fluorocyclobutanecarboxylic acid manufacturer3-Fluorocyclobutanecarboxylic acid price3-Fluorocyclobutanecarboxylic acid structure3-Fluorocyclobutanecarboxylic acid SDSbuy 3-Fluorocyclobutanecarboxylic acid3-Fluorocyclobutanecarboxylic acid supplier3-Fluorocyclobutanecarboxylic acid uses3-Fluorocyclobutanecarboxylic acid molecular weightprice of 3-Fluorocyclobutanecarboxylic acid3-Fluorocyclobutanecarboxylic acid chemical name formula of 3-Fluorocyclobutanecarboxylic acid
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label