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Structure of 35203-91-9
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Quinoline-8-sulfonamide features a rigid heteroaromatic core paired with a sulfonamide group at the C8 position, enabling strong hydrogen bonding and enhanced solubility. This scaffold integrates readily into medicinal chemistry libraries, offering favorable pharmacokinetic properties and serving as a key building block for kinase inhibitors and antimicrobial agents.
Quinoline-8-sulfonamide serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through well-established coupling reactions. Its sulfonamide group exhibits favorable solubility and hydrogen-bonding capacity, enhancing target engagement potential. The quinoline scaffold provides metabolic stability and facilitates π–π stacking interactions in biological targets. This compound demonstrates robust bench stability and compatibility with standard purification protocols, making it a practical choice for lead optimization campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H317-H319
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Precautionary Statements : P261-P264-P272-P280-P302+P352-P362+P364-P501
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Lot numbers can be found on the outside label of a product: