4-Bromo-2-chlorobenzene-1-sulfonyl chloride

Name: 4-Bromo-2-chlorobenzene-1-sulfonyl chloride
Brand: ChemScene
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CAS No. 351003-52-6
Cat. No. CS-W012203
Purity≥97%
MDL No.MFCD03094630

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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4-Bromo-2-chlorobenzene-1-sulfonyl chloride|CS-W012203

Structure of 351003-52-6

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General Information

CAS No. 351003-52-6
Cat. No. CS-W012203
Purity ≥97%
MDL No. MFCD03094630
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃BrCl₂O₂S
Molecular Weight 289.96
Synonym(s) Benzenesulfonyl chloride, 4-bromo-2-chloro-
SMILES ClC1=C(C=CC(Br)=C1)S(Cl)(=O)=O

Description

4-Bromo-2-chlorobenzene-1-sulfonyl chloride features a dual halogenated aromatic core with orthogonal reactivity, enabling selective coupling in complex molecule assembly. The sulfonyl chloride group delivers high electrophilicity under mild conditions, facilitating efficient amide and sulfonamide formation. This bench-stable reagent offers predictable regiochemistry and enhanced solubility in common organic solvents.

Application

4-Bromo-2-chlorobenzene-1-sulfonyl chloride serves as a versatile electrophilic sulfonylating agent, enabling efficient introduction of the sulfonyl group into aromatic and heteroaromatic systems. Its dual halogen substituents enhance regioselective functionalization in cross-coupling and nucleophilic substitution reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it a practical choice for constructing sulfonamide-based scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

TPSA 34.14
LogP 3.03
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-Bromo-2-chlorobenzene-1-sulfonyl chloride

CAS No. 351003-52-6

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