3,4,5-Trifluorobenzenesulfonyl chloride

Name: 3,4,5-Trifluorobenzenesulfonyl chloride
Brand: ChemScene
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CAS No. 351003-43-5
Cat. No. CS-0127976
Purity≥96%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3,4,5-Trifluorobenzenesulfonyl chloride|CS-0127976

Structure of 351003-43-5

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General Information

CAS No. 351003-43-5
Cat. No. CS-0127976
Purity ≥96%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂ClF₃O₂S
Molecular Weight 230.59
Synonym(s) 3,4,5-Trifluorobenzenesulphonyl chloride
SMILES O=S(C1=CC(F)=C(C(F)=C1)F)(Cl)=O

Description

3,4,5-Trifluorobenzenesulfonyl chloride features a highly electron-deficient aromatic ring that enhances reactivity in sulfonylation processes. This bench-stable reagent facilitates efficient introduction of sulfonate groups into nucleophilic substrates under mild conditions, offering superior selectivity and yield in synthetic applications.

Application

3,4,5-Trifluorobenzenesulfonyl chloride serves as a highly reactive sulfonylating agent for the efficient introduction of trifluoromethyl-substituted sulfonamide groups. Its electron-deficient aromatic ring enhances electrophilicity, enabling rapid reaction with amines and alcohols under mild conditions. The compound exhibits excellent bench stability and facilitates clean, high-yielding transformations, making it ideal for constructing fluorinated sulfonamide building blocks in medicinal chemistry and agrochemical synthesis.

Safety Information

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GHS Pictogram :	GHS No : GHS02,GHS05
Signal Word : Danger	UN#: 2924
Class : 3,8	Packing Group : Ⅲ
Hazard Statements : H225-H314
Precautionary Statements : P210-P240-P241-P280-P370+P378

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Computational Chemistry Data

TPSA 34.14
LogP 2.0314
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Sulfonyl Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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3,4,5-Trifluorobenzenesulfonyl chloride

CAS No. 351003-43-5

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