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CS-W001157 4
Total: USD 88.00

2,4,6-Trifluorobenzene-1-sulfonyl chloride

  • CAS No. 220239-64-5

  • Cat. No. CS-W010371
  • Purity≥98%
  • MDL No.MFCD01091015

*For research and further manufacturing use only, not for direct human use.

2,4,6-Trifluorobenzene-1-sulfonyl chloride|CS-W010371

Structure of 220239-64-5

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General Information

  • CAS No. 220239-64-5
  • Cat. No. CS-W010371
  • Purity ≥98%
  • MDL No. MFCD01091015
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂ClF₃O₂S
  • Molecular Weight 230.59
  • Synonym(s) 2,4,6-trifluorobenzenesulfonyl Chloride
  • SMILES O=S(C1=C(F)C=C(F)C=C1F)(Cl)=O

Application

2,4,6-Trifluorobenzene-1-sulfonyl chloride serves as a highly effective sulfonylating agent for the synthesis of sulfonamide derivatives. Its electron-deficient aromatic ring enhances reactivity while maintaining bench stability, enabling efficient coupling with amines under mild conditions. The trifluoromethyl group imparts excellent functional group tolerance and facilitates purification via crystallization or chromatography. This reagent functions reliably in the construction of bioactive scaffolds and pharmaceutical intermediates where enhanced metabolic stability is required.

Synthesis

  • Route1
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    • ~%
    • In-stock
      2,4,6-Trifluorobenzene-1-sulfonyl chloride|CS-W010371
      220239-64-5

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 13 p. 1843 - 1846

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   34.14
  • LogP   2.0314
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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