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CS-W001157 4
Total: USD 88.00

5-Fluoro-1H-indazole

  • CAS No. 348-26-5

  • Cat. No. CS-W009120
  • Purity≥97%
  • MDL No.MFCD04972877

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-1H-indazole|CS-W009120

Structure of 348-26-5

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General Information

  • CAS No. 348-26-5
  • Cat. No. CS-W009120
  • Purity ≥97%
  • MDL No. MFCD04972877
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅FN₂
  • Molecular Weight 136.13
  • Synonym(s) 5-Fluoroindazole
  • SMILES FC1=CC2=C(C=C1)NN=C2

Description

5-Fluoro-1H-indazole is a heterocyclic scaffold featuring a fluorinated indazole core, offering enhanced electronic and metabolic stability. This compound integrates readily into pharmaceutical intermediates and functional materials due to its electron-deficient aromatic system and favorable bioavailability profile under standard conditions.

Application

5-Fluoro-1H-indazole serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of bioactive scaffolds through established coupling reactions. Its electron-deficient aromatic system enhances reactivity in palladium-catalyzed cross-couplings, while the fluorine substituent provides metabolic stability and modulates electronic properties. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for scalable synthesis and API development workflows.

Synthesis

  • Route1

    References

    • Shimada, Itsuro; Maeno, Kyoichi; Kazuta, Ken-ichi; Kubota, Hideki; Kimizuka, Tetsuya; Kimura, Yasuharu; Hatanaka, Ken-ichi; Naitou, Yuki; Wanibuchi, Fumikazu; Sakamoto, Shuichi; Tsukamoto, Shin-ichi Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 4 p. 1966 - 1982
  • Route2

    References

    • Wrzeciono; Majewska; Buge; Kohler; Rickinger; Nuhn Pharmazie, 1992 , vol. 47, # 1 p. 22 - 24

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   1.702
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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