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CS-W001157 4
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7-Fluoro-1H-indazole

  • CAS No. 341-24-2

  • Cat. No. CS-W019999
  • Purity≥98%
  • MDL No.MFCD09026976

*For research and further manufacturing use only, not for direct human use.

7-Fluoro-1H-indazole|CS-W019999

Structure of 341-24-2

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General Information

  • CAS No. 341-24-2
  • Cat. No. CS-W019999
  • Purity ≥98%
  • MDL No. MFCD09026976
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅FN₂
  • Molecular Weight 136.13
  • Synonym(s) 7-FLUORO INDAZOLE
  • SMILES FC1=CC=CC2=C1NN=C2

Description

7-Fluoro-1H-indazole is a bench-stable, electron-deficient heterocycle featuring a fluorine atom at the 7-position, enhancing its reactivity in cross-coupling and electrophilic substitution. This indazole scaffold integrates readily into bioactive molecules, offering improved metabolic stability and membrane permeability.

Application

7-Fluoro-1H-indazole serves as a versatile heterocyclic building block in medicinal chemistry, enabling direct incorporation of fluorine into bioactive scaffolds. Its electron-deficient aromatic core facilitates electrophilic substitution and transition-metal-catalyzed coupling reactions, while the indazole nitrogen atoms support selective functionalization. The compound exhibits good bench stability and compatibility with common purification methods, making it suitable for high-throughput synthesis and API development workflows.

Synthesis

  • Route1

    References

    • Kirin Pharma Kabushiki Kaisha Patent: EP1870414 A1, 2007 ; Location in patent: Page/Page column 23 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   1.702
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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