Methyl 2-chloro-4-methoxynicotinate

Name: Methyl 2-chloro-4-methoxynicotinate
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CAS No. 344298-51-7
Cat. No. CS-0042702
Purity≥96%
MDL No.MFCD18378508

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Methyl 2-chloro-4-methoxynicotinate|CS-0042702

Structure of 344298-51-7

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General Information

CAS No. 344298-51-7
Cat. No. CS-0042702
Purity ≥96%
MDL No. MFCD18378508
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈ClNO₃
Molecular Weight None
Synonym(s) 2-Chloro-4-methoxy-3-pyridinecarboxylic acid methyl ester
SMILES O=C(OC)C1=C(Cl)N=CC=C1OC

Description

Methyl 2-chloro-4-methoxynicotinate is a bench-stable, moisture-tolerant heterocyclic ester featuring a chlorine atom at the 2-position and a methoxy group at the 4-position of the pyridine ring. This electron-deficient scaffold integrates readily into synthetic sequences requiring directed functionalization, enabling efficient access to bioactive analogs through palladium-catalyzed cross-coupling and nucleophilic substitution reactions.

Application

Methyl 2-chloro-4-methoxynicotinate serves as a versatile building block in medicinal chemistry and heterocyclic synthesis. Its ortho-chloro and meta-methoxy substituents enable selective functionalization, facilitating palladium-catalyzed cross-couplings and nucleophilic substitution reactions. The ester group supports further transformations including hydrolysis and derivatization. Bench-stable and readily purified by crystallization, it functions efficiently in the construction of bioactive scaffolds and API intermediates.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 48.42
LogP 1.5302
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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Methyl 2-chloro-4-methoxynicotinate

CAS No. 344298-51-7

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