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Structure of 343788-51-2
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8-(Benzyloxy)-2-chloroquinoline features a benzyl ether substituent at the 8-position paired with a chlorine atom at the 2-position, delivering enhanced solubility and electronic modulation. This structural combination enables direct incorporation into bioactive scaffolds, particularly in kinase inhibitor development and fluorescent probe design, under standard bench conditions.
8-(Benzyloxy)-2-chloroquinoline serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C2 position via palladium-catalyzed cross-coupling reactions. The benzyloxy group provides orthogonal protection and enhances solubility, while the chloro substituent offers high reactivity in Suzuki, Negishi, and Buchwald–Hartwig couplings. Its bench-stable nature and compatibility with diverse reaction conditions facilitate efficient synthesis of quinoline-based pharmaceutical scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: