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CS-W001157 4
Total: USD 88.00

4-Chloro-3-(trifluoromethyl)benzaldehyde

  • CAS No. 34328-46-6

  • Cat. No. CS-W008104
  • Purity≥96%
  • MDL No.MFCD00040722

*For research and further manufacturing use only, not for direct human use.

4-Chloro-3-(trifluoromethyl)benzaldehyde|CS-W008104

Structure of 34328-46-6

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General Information

  • CAS No. 34328-46-6
  • Cat. No. CS-W008104
  • Purity ≥96%
  • MDL No. MFCD00040722
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄ClF₃O
  • Molecular Weight 208.57
  • Synonym(s) 2-Chloro-5-formylbenzotrifluoride
  • SMILES C1=C(C=CC(=C1C(F)(F)F)Cl)C=O

Description

4-Chloro-3-(trifluoromethyl)benzaldehyde features a trifluoromethyl group that enhances electron-withdrawing character and metabolic stability, while the ortho-chloro substituent provides steric and electronic modulation. This combination delivers high reactivity in nucleophilic addition and coupling reactions, enabling efficient access to functionalized aryl scaffolds under standard conditions.

Application

4-Chloro-3-(trifluoromethyl)benzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of biologically active heterocycles. Its electron-deficient aromatic core facilitates nucleophilic substitution and coupling reactions, while the aldehyde group supports reductive amination, Wittig transformations, and imine formation. The trifluoromethyl and chloro substituents enhance metabolic stability and modulate electronic properties, offering favorable handling and purification characteristics for scalable synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.1713
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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