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CS-W001157 4
Total: USD 88.00

Mal-PEG2-alcohol

  • CAS No. 34321-81-8

  • Cat. No. CS-0114870
  • Purity≥98%
  • MDL No.MFCD16780862

*For research and further manufacturing use only, not for direct human use.

Mal-PEG2-alcohol|CS-0114870

Structure of 34321-81-8

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General Information

  • CAS No. 34321-81-8
  • Cat. No. CS-0114870
  • Purity ≥98%
  • MDL No. MFCD16780862
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁NO₄
  • Molecular Weight 185.18
  • Synonym(s) None
  • SMILES O=C(C=C1)N(CCOCCO)C1=O

Description

Mal-PEG2-alcohol features a maleimide group conjugated to a short, hydrophilic PEG2 spacer terminating in a primary alcohol. This structure enables site-specific bioconjugation via thiol-Michael addition, while the terminal OH group supports further derivatization or immobilization. The PEG2 linker enhances solubility and reduces aggregation, making it suitable for protein labeling and probe synthesis under physiological conditions.

Application

Mal-PEG2-alcohol serves as a versatile bifunctional linker for conjugation and polymer synthesis. The maleimide group enables efficient, selective Michael addition with thiols under physiological conditions, while the terminal primary alcohol facilitates further derivatization via esterification or etherification. Its short PEG spacer provides enhanced solubility and reduced steric hindrance, making it ideal for bioconjugation applications requiring precise spacing and stability.

Synthesis

  • Route1
    • In-stock
      Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate|CS-W008141
      55750-48-6
    • null|null
      929-06-6
    • ~92%
    • In-stock
      Mal-PEG2-alcohol|CS-0114870
      34321-81-8

    References

    • Heredia, Karina L.; Bontempo, Debora; Ly, Tiffany; Byers, Joshua T.; Halstenberg, Sven; Maynard, Heather D. Journal of the American Chemical Society, 2005 , vol. 127, # 48 p. 16955 - 16960
  • Route2
    • In-stock
      Ethyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate|CS-0151559
      55750-49-7
    • null|null
      929-06-6
    • ~%
    • In-stock
      Mal-PEG2-alcohol|CS-0114870
      34321-81-8

    References

    • Raouane, Mouna; Desmaele, Didier; Gilbert-Sirieix, Marie; Gueutin, Claire; Zouhiri, Fatima; Bourgaux, Claudie; Lepeltier, Elise; Gref, Ruxandra; Ben Salah, Ridha; Clayman, Gary; Massaad-Massade, Liliane; Couvreur, Patrick Journal of Medicinal Chemistry, 2011 , vol. 54, # 12 p. 4067 - 4076

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P501

Quality Control

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   -1.0797
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   5

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