Lot numbers can be found on the outside label of a product:
3-Bromo-2,6-dimethylpyridine
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CAS No. 3430-31-7
- Cat. No. CS-W002566
- Purity≥98%
- MDL No.MFCD00235164
*For research and further manufacturing use only, not for direct human use.
Structure of 3430-31-7
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General Information
- CAS No. 3430-31-7
- Cat. No. CS-W002566
- Purity ≥98%
- MDL No. MFCD00235164
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₈BrN
- Molecular Weight 186.05
- Synonym(s) 2,6-Dimethyl-3-bromopyridine
- SMILES CC1=NC(C)=C(Br)C=C1
Description
3-Bromo-2,6-dimethylpyridine features a pyridine core with strategically positioned bromo and methyl groups, enabling selective functionalization in cross-coupling reactions. The electron-deficient ring and steric shielding from adjacent methyl substituents enhance reactivity control and stability under standard conditions. This compound serves as a key building block for bioactive heterocycles and advanced ligands.
Application
3-Bromo-2,6-dimethylpyridine serves as a versatile building block in medicinal chemistry and catalytic synthesis, enabling direct functionalization at the C3 position via palladium-catalyzed cross-coupling reactions. The methyl groups at C2 and C6 provide steric protection and enhance stability, while the bromine facilitates reliable coupling with arylboranes, organotin reagents, and amines. Its bench-stable, crystalline form simplifies handling and purification in multi-step syntheses.
Synthesis
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Route1
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108-48-5 - ~56%
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In-stock
3430-31-7
References
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Zimmermann, Nicole; Meggers, Eric; Schultz, Peter G. Bioorganic Chemistry, 2004 , vol. 32, # 1 p. 13 - 25
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Route2
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108-48-5
- ~9%
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In-stock
3430-31-7
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In-stock
3430-34-0
References
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Zeitschrift fuer Chemie (Stuttgart, Germany), , vol. 28, # 2 p. 59 - 60
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Route3
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In-stock
625-84-3 -
75-25-2
- ~%
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In-stock
3430-31-7
References
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Gazzetta Chimica Italiana, , vol. 30 I, p. 94
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1760
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H227-H315-H318-H335
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Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 12.89
- LogP 2.46094
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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