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(3-endo)-8-(1-Methylethyl)-8-azabicyclo[3.2.1]octan-3-ol

  • CAS No. 3423-25-4

  • Cat. No. CS-0197164
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3-endo)-8-(1-Methylethyl)-8-azabicyclo[3.2.1]octan-3-ol|CS-0197164

Structure of 3423-25-4

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General Information

  • CAS No. 3423-25-4
  • Cat. No. CS-0197164
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₉NO
  • Molecular Weight 169.26
  • Synonym(s) endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol
  • SMILES CC(C)N1[C@H]2CC[C@@H]1C[C@@H](C2)O

Description

This bicyclic alcohol features a tertiary hydroxyl group at the 3-endo position, flanked by a sterically hindered 8-azabicyclo[3.2.1]octane scaffold and a (1-methylethyl) substituent at C8. The configuration imparts rigidity and defined stereochemistry, making it suitable for asymmetric synthesis and medicinal chemistry applications where controlled three-dimensional structure is essential.

Application

(3-endo)-8-(1-Methylethyl)-8-azabicyclo[3.2.1]octan-3-ol serves as a rigid, conformationally defined bicyclic scaffold with well-established utility in medicinal chemistry. Its tertiary alcohol and nitrogen-bearing framework enable straightforward functionalization, including oxidation and derivatization, while maintaining excellent bench stability. The molecule functions effectively as a key building block for heterocyclic systems and bioactive compound synthesis, offering predictable stereochemistry and favorable handling characteristics in standard organic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   1.3825
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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