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CS-W001157 4
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6-Chloro-5-quinolinamine

  • CAS No. 341010-40-0

  • Cat. No. CS-0019054
  • Molecule weight178.62
  • Purity≥98%
  • MDL No.MFCD02947117

*For research and further manufacturing use only, not for direct human use.

6-Chloro-5-quinolinamine|CS-0019054

Structure of 341010-40-0

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General Information

  • CAS No. 341010-40-0
  • Cat. No. CS-0019054
  • Purity ≥98%
  • MDL No. MFCD02947117
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇ClN₂
  • Molecular Weight 178.62
  • Synonym(s) 6-Chloroquinolin-5-amine; 5-Amino-6-chloroquinoline
  • SMILES NC1=C2C=CC=NC2=CC=C1Cl

Description

6-Chloro-5-quinolinamine delivers a reactive chloro substituent at the 6-position and a primary amine at the 5-position on the quinoline scaffold. This configuration enables direct coupling reactions in medicinal chemistry and materials synthesis, where regioselective functionalization is critical. The molecule exhibits favorable solubility in common organic solvents and stability under standard bench conditions.

Application

6-Chloro-5-quinolinamine serves as a versatile building block in medicinal chemistry, enabling direct coupling reactions via its amino and chloro functionalities. The ortho-chloro group facilitates palladium-catalyzed cross-coupling, while the primary amine supports derivatization through acylation or azo coupling. Its stability under standard reaction conditions and compatibility with diverse functional groups make it a practical reagent for constructing quinoline-based scaffolds in API development.

Synthesis

  • Route1

    References

    • Journal fuer Praktische Chemie (Leipzig), , vol. <2> 49, p. 365
  • Route2

    References

    • Journal fuer Praktische Chemie (Leipzig), , vol. <2> 49, p. 365
  • Route3

    References

    • Journal fuer Praktische Chemie (Leipzig), , vol. <2> 49, p. 365

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.4704
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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