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CS-W001157 4
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8-Chloroquinolin-7-amine

  • CAS No. 1379334-91-4

  • Cat. No. CS-0199313
  • Molecule weight178.62
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

8-Chloroquinolin-7-amine|CS-0199313

Structure of 1379334-91-4

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General Information

  • CAS No. 1379334-91-4
  • Cat. No. CS-0199313
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇ClN₂
  • Molecular Weight 178.62
  • Synonym(s) 8-Chloro-7-quinolinamine
  • SMILES C1=CC2=C(C(=C(C=C2)N)Cl)N=C1

Description

8-Chloroquinolin-7-amine is a heterocyclic amine featuring a chlorine atom at the 8-position and a primary amine at the 7-position of the quinoline scaffold. This electron-deficient architecture enables direct incorporation into metal-ligand complexes and facilitates C–N coupling reactions under mild conditions. The molecule exhibits enhanced solubility in polar organic solvents and stability under ambient handling, making it a practical building block for pharmaceutical intermediates and functional materials.

Application

8-Chloroquinolin-7-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of quinoline-based scaffolds. Its chlorine and amine functionalities provide orthogonal reactivity for Suzuki-Miyaura couplings, nucleophilic substitutions, and metal-catalyzed C–H functionalizations. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in API development and target-oriented discovery.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.4704
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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