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CS-W001157 4
Total: USD 88.00

Diethyl 2-chloro-3-oxosuccinate

  • CAS No. 34034-87-2

  • Cat. No. CS-W013109
  • Purity≥90%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Diethyl 2-chloro-3-oxosuccinate|CS-W013109

Structure of 34034-87-2

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General Information

  • CAS No. 34034-87-2
  • Cat. No. CS-W013109
  • Purity ≥90%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁ClO₅
  • Molecular Weight 222.62
  • Synonym(s) Diethyl Chlorooxalacetate
  • SMILES O=C(OCC)C(Cl)C(C(OCC)=O)=O

Description

Diethyl 2-chloro-3-oxosuccinate is a reactive diester featuring a chlorine-substituted α-carbon adjacent to two carbonyl groups. This electrophilic site enables efficient alkylation and condensation reactions in synthetic pathways. The molecule's stability under standard conditions facilitates straightforward handling, making it valuable for constructing complex heterocycles and functionalized intermediates in organic synthesis.

Application

Diethyl 2-chloro-3-oxosuccinate serves as a versatile synthon in heterocyclic synthesis, enabling efficient access to chlorinated β-keto ester derivatives. Its α-chloro ketone functionality facilitates nucleophilic substitution and condensation reactions, particularly in the construction of substituted pyrroles, furans, and other medicinally relevant scaffolds. The molecule exhibits good bench stability and compatibility with standard purification techniques, making it a practical choice for iterative synthetic campaigns in medicinal chemistry and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302+H312-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P302+P352-P304+P340-P330-P362+P364-P363-P405-P501

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Computational Chemistry Data

  • TPSA   69.67
  • LogP   0.2891
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   5

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