Tetrahydro-2H-pyran-4-sulfonyl chloride

Name: Tetrahydro-2H-pyran-4-sulfonyl chloride
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CAS No. 338453-21-7
Cat. No. CS-0110640
Purity≥95%
MDL No.MFCD07787616

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Tetrahydro-2H-pyran-4-sulfonyl chloride|CS-0110640

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General Information

CAS No. 338453-21-7
Cat. No. CS-0110640
Purity ≥95%
MDL No. MFCD07787616
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₉ClO₃S
Molecular Weight 184.64
Synonym(s) Tetrahydropyran-4-SulfonylChloride
SMILES O=S(C1CCOCC1)(Cl)=O

Description

Tetrahydro-2H-pyran-4-sulfonyl chloride serves as a robust sulfonylating agent for selective functionalization of alcohols and amines. The tetrahydropyranyl protecting group enhances solubility and stability under standard conditions, while the sulfonyl chloride moiety enables efficient coupling reactions with minimal side reactivity. This reagent streamlines the synthesis of sulfonamide and sulfonate derivatives in complex molecule assembly.

Application

Tetrahydro-2H-pyran-4-sulfonyl chloride serves as a robust sulfonylating agent for the selective introduction of sulfonate groups under mild conditions. Its bench-stable nature and compatibility with diverse functional groups enable efficient synthesis of sulfonamide intermediates, glycosyl sulfonates, and protected heterocyclic scaffolds. The tetrahydropyranyl moiety provides orthogonal protection, facilitating sequential transformations in complex molecule assembly.

Safety Information

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GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H314-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P312-P330-P363-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 43.37
LogP 0.734
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Tetrahydropyran compounds

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Tetrahydro-2H-pyran-4-sulfonyl chloride

CAS No. 338453-21-7

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