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CS-W001157 4
Total: USD 88.00

Bis(2-chloroethyl)amine

  • CAS No. 334-22-5

  • Cat. No. CS-0662923
  • Purity≥96%
  • MDL No.MFCD00128968

*For research and further manufacturing use only, not for direct human use.

Bis(2-chloroethyl)amine|CS-0662923

Structure of 334-22-5

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General Information

  • CAS No. 334-22-5
  • Cat. No. CS-0662923
  • Purity ≥96%
  • MDL No. MFCD00128968
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉Cl₂N
  • Molecular Weight 142.03
  • Synonym(s) None
  • SMILES ClCCNCCCl

Description

Bis(2-chloroethyl)amine is a bifunctional alkylating agent featuring two reactive chloroethyl groups. This compound readily forms covalent cross-links with nucleophilic sites in biomolecules, enabling targeted conjugation in synthetic and biochemical applications. The molecule's high reactivity under mild conditions facilitates efficient derivatization of proteins, nucleic acids, and other functionalized substrates.

Application

Bis(2-chloroethyl)amine serves as a versatile bifunctional electrophile in synthetic organic chemistry, enabling efficient intramolecular cyclization to form aziridine rings under mild conditions. Its two reactive chloroethyl groups facilitate rapid alkylation of nucleophiles, making it valuable for the construction of nitrogen-containing heterocycles and as a building block in peptide conjugation strategies. The compound exhibits good bench stability and is compatible with a range of functional groups, supporting its use in iterative synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.0536
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   4

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