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CS-W001157 4
Total: USD 88.00

6-Nitronicotinic acid

  • CAS No. 33225-73-9

  • Cat. No. CS-W003159
  • Purity≥96%
  • MDL No.MFCD04114183

*For research and further manufacturing use only, not for direct human use.

6-Nitronicotinic acid|CS-W003159

Structure of 33225-73-9

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General Information

  • CAS No. 33225-73-9
  • Cat. No. CS-W003159
  • Purity ≥96%
  • MDL No. MFCD04114183
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄N₂O₄
  • Molecular Weight 168.11
  • Synonym(s) 6-nitropyridine-3-carboxylicaci; 6-Nitronicotinic acid
  • SMILES OC(=O)c1ccc(nc1)[N+](=O)[O-]

Description

6-Nitronicotinic acid features a nitro group positioned at the 6-position of the nicotinic acid scaffold, imparting strong electron-withdrawing character. This configuration enhances acidity and influences reactivity in electrophilic substitution and coupling processes. The molecule integrates readily into bioactive heterocycles and serves as a key intermediate in pharmaceutical synthesis under standard conditions.

Application

6-Nitronicotinic acid serves as a versatile building block in heterocyclic synthesis, enabling direct access to nitro-substituted pyridine scaffolds relevant to medicinal chemistry and agrochemical development. Its ortho-nitro functionality facilitates subsequent transformations such as reduction to amino derivatives or metal-catalyzed cross-couplings. The compound exhibits good bench stability and is readily purified by recrystallization, supporting its use in multi-step synthetic sequences requiring functional group compatibility and predictable reactivity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   93.33
  • LogP   0.688
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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