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CS-W001157 4
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Glycyl-L-phenylalanine

  • CAS No. 3321-03-7

  • Cat. No. CS-W014714
  • Purity≥95%
  • MDL No.MFCD00065110

*For research and further manufacturing use only, not for direct human use.

Glycyl-L-phenylalanine|CS-W014714

Structure of 3321-03-7

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General Information

  • CAS No. 3321-03-7
  • Cat. No. CS-W014714
  • Purity ≥95%
  • MDL No. MFCD00065110
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₄N₂O₃
  • Molecular Weight 222.24
  • Synonym(s) Gly-Phe; H-Gly-Phe-OH
  • SMILES O=C(O)[C@H](CC1=CC=CC=C1)NC(CN)=O

Description

Glycyl-L-phenylalanine is a dipeptide featuring a glycine residue linked via a peptide bond to L-phenylalanine. This compound exhibits enhanced solubility in aqueous and polar organic solvents, facilitating use in synthetic peptide workflows. The aromatic side chain of phenylalanine imparts hydrophobic character, enabling applications in membrane-protein studies and ligand design. Its bench-stable nature supports reliable handling under standard laboratory conditions.

Application

Glycyl-L-phenylalanine serves as a stable dipeptide building block for peptide synthesis, offering reliable coupling efficiency and compatibility with standard Fmoc-SPPS protocols. Its well-defined stereochemistry and orthogonal functional group tolerance facilitate seamless incorporation into larger peptide sequences, enabling precise access to bioactive motifs and pharmaceutical scaffolds.

Synthesis

  • Route1

    References

    • Chemische Berichte, , vol. 91, p. 449,453
  • Route2
    • L-Phenylalanine Aspartame Impurity|CS-0229723
      63-91-2
    • ~%
    • In-stock
      Glycyl-L-phenylalanine|CS-W014714
      3321-03-7

    References

    • Journal of Medicinal Chemistry, , vol. 43, # 4 p. 664 - 674
  • Route3
    • null|null
      125982-40-3
    • ~%
    • In-stock
      Glycyl-L-phenylalanine|CS-W014714
      3321-03-7

    References

    • Tetrahedron Letters, , vol. 30, # 26 p. 3413 - 3414

Safety Information

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GHS Pictogram : N/A
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Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

  • TPSA   92.42
  • LogP   -0.2428
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   5

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