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CS-W001157 4
Total: USD 88.00

2-(3-Fluorophenyl)acetic acid

  • CAS No. 331-25-9

  • Cat. No. CS-W004799
  • Purity≥98%
  • MDL No.MFCD00004331

*For research and further manufacturing use only, not for direct human use.

2-(3-Fluorophenyl)acetic acid|CS-W004799

Structure of 331-25-9

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General Information

  • CAS No. 331-25-9
  • Cat. No. CS-W004799
  • Purity ≥98%
  • MDL No. MFCD00004331
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₂
  • Molecular Weight 154.14
  • Synonym(s) 3-Fluorophenylacetic acid
  • SMILES C1=C(C=CC=C1F)CC(O)=O

Description

2-(3-Fluorophenyl)acetic acid features a fluorinated aromatic ring that enhances metabolic stability and lipophilicity, enabling effective integration into bioactive scaffolds. This bench-stable, moisture-tolerant carboxylic acid facilitates direct coupling in peptide synthesis and serves as a key building block for pharmaceutical intermediates.

Application

2-(3-Fluorophenyl)acetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive molecules through standard functional group transformations. Its fluorinated aryl moiety enhances metabolic stability and modulates electronic properties, while the carboxylic acid group facilitates coupling reactions, derivatization, and incorporation into heterocyclic scaffolds. The compound exhibits good bench stability and is compatible with common purification methods, making it a practical choice for iterative synthesis campaigns.

Synthesis

  • Route1
    • null|null
      201230-82-2
    • null|null
      456-42-8
    • ~81%
    • In-stock
      2-(3-Fluorophenyl)acetic acid|CS-W004799
      331-25-9

    References

    • She, Meng-Yao; Xiao, Da-Wei; Yin, Bing; Yang, Zheng; Liu, Ping; Li, Jian-Li; Shi, Zhen Tetrahedron, 2013 , vol. 69, # 35 p. 7264 - 7268
  • Route2

    References

    • US4578387 A1, ;
  • Route3
    • null|null
      352-70-5
    • ~%
    • In-stock
      2-(3-Fluorophenyl)acetic acid|CS-W004799
      331-25-9

    References

    • Journal of the American Chemical Society, , vol. 85, p. 709 - 724

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.4528
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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