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Furo[3,2-c]pyridin-4-amine
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CAS No. 33007-09-9
- Cat. No. CS-0199091
- Purity≥95%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
![Furo[3,2-c]pyridin-4-amine|CS-0199091](https://file.chemscene.com/productPIC/CS-0199091.gif)
Structure of 33007-09-9
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General Information
- CAS No. 33007-09-9
- Cat. No. CS-0199091
- Purity ≥95%
- MDL No. None
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₆N₂O
- Molecular Weight 134.14
- Synonym(s) 4-aminofuro[3,2-c]pyridine
- SMILES N=1C=CC=2OC=CC2C1N
Description
Furo[3,2-c]pyridin-4-amine delivers a rigid, electron-rich heterocyclic scaffold ideal for constructing bioactive molecules. This bench-stable compound integrates readily into medicinal chemistry campaigns, offering enhanced solubility and metabolic stability. Its nitrogen-rich core enables efficient coupling reactions, facilitating the development of targeted therapeutics.
Application
Furo[3,2-c]pyridin-4-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to fused polycyclic scaffolds. Its pyridine nitrogen and amine functionality offer orthogonal reactivity for downstream derivatization, while the furan moiety enhances planarity and π-stacking potential. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns targeting kinase inhibitors and other bioactive molecules.
Synthesis
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Route1
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In-stock
![4-Chlorofuro[3,2-c]pyridine|CS-W002916](https://file.chemscene.com/productPIC/CS-W002916.gif)
31270-80-1 - ~88%
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In-stock
33007-09-9
References
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BRISTOL-MYERS SQUIBB COMPANY; COOK II, James H.; MCDONALD, Ivar, M.; KING, Dalton; OLSON, Richard, E.; WANG, Nenghui; IWUAGWU, Christiana, I.; ZUSI, Christopher, F.; MACOR, John, E. Patent: WO2011/53292 A1, 2011 ; Location in patent: Page/Page column 135 ; WO 2011/053292 A1
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Route2
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In-stock
31270-80-1
- ~%
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42398-75-4 -
In-stock
33007-09-9
References
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Akzo Nobel N.V. Patent: US6194409 B1, 2001 ;
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Route3
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In-stock
![Furo[3,2-c]pyridin-4(5H)-one|CS-W002486](https://file.chemscene.com/productPIC/CS-W002486.gif)
26956-43-4 - ~%
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In-stock
33007-09-9
References
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Bourzat,J.-D.; Bisagni,E. Bulletin de la Societe Chimique de France, 1971 , p. 1727 - 1730
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 52.05
- LogP 1.41
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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