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CS-W001157 4
Total: USD 88.00

3-(Trifluoromethyl)benzohydrazide

  • CAS No. 22227-25-4

  • Cat. No. CS-0449732
  • Molecule weight204.15
  • Purity≥97%
  • MDL No.MFCD00221476

*For research and further manufacturing use only, not for direct human use.

3-(Trifluoromethyl)benzohydrazide|CS-0449732

Structure of 22227-25-4

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General Information

  • CAS No. 22227-25-4
  • Cat. No. CS-0449732
  • Purity ≥97%
  • MDL No. MFCD00221476
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇F₃N₂O
  • Molecular Weight 204.15
  • Synonym(s) 3-(TRIFLUOROMETHYL)BENZOIC ACID HYDRAZIDE
  • SMILES FC(F)(F)C1=CC=CC(C(NN)=O)=C1

Description

3-(Trifluoromethyl)benzohydrazide features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability. This compound integrates readily into hydrazone-based conjugation strategies, offering improved solubility and reactivity under standard bench conditions.

Application

3-(Trifluoromethyl)benzohydrazide serves as a versatile building block in medicinal chemistry, enabling the construction of hydrazine-containing heterocycles and bioactive scaffolds. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the hydrazide functionality facilitates condensation reactions with aldehydes and ketones to form hydrazones—key intermediates in drug discovery workflows. The compound exhibits good bench stability and is readily purified by recrystallization, supporting its use in scalable synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   1.3089
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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