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CS-W001157 4
Total: USD 88.00

(3-Fluoro-5-formylphenyl)boronic acid

  • CAS No. 328956-60-1

  • Cat. No. CS-0101375
  • Purity≥98%
  • MDL No.MFCD11856017

*For research and further manufacturing use only, not for direct human use.

(3-Fluoro-5-formylphenyl)boronic acid|CS-0101375

Structure of 328956-60-1

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General Information

  • CAS No. 328956-60-1
  • Cat. No. CS-0101375
  • Purity ≥98%
  • MDL No. MFCD11856017
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BFO₃
  • Molecular Weight 167.93
  • Synonym(s) 3-Fluoro-5-formylphenylboronic acid
  • SMILES O=CC1=CC(F)=CC(B(O)O)=C1

Description

This boronic acid features a fluorinated aryl ring paired with a formyl group, enabling selective coupling in Suzuki-Miyaura reactions. The electron-deficient aromatic system enhances reactivity while maintaining bench-stable handling under standard conditions.

Application

(3-Fluoro-5-formylphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling the efficient construction of biaryl scaffolds with precise substitution patterns. The formyl group provides orthogonal reactivity for downstream modifications, including oxime formation or reductive amination, while the boronic acid functionality ensures compatibility with aqueous conditions and mild reaction parameters. Bench-stable and readily purified by recrystallization, it facilitates streamlined synthesis of functionalized aromatic systems relevant to medicinal chemistry and materials science.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   -0.682
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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