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CS-W001157 4
Total: USD 88.00

2-(1H-1,2,4-Triazol-1-yl)ethan-1-ol

  • CAS No. 3273-14-1

  • Cat. No. CS-0179616
  • Purity≥97%
  • MDL No.MFCD00607979

*For research and further manufacturing use only, not for direct human use.

2-(1H-1,2,4-Triazol-1-yl)ethan-1-ol|CS-0179616

Structure of 3273-14-1

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General Information

  • CAS No. 3273-14-1
  • Cat. No. CS-0179616
  • Purity ≥97%
  • MDL No. MFCD00607979
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₇N₃O
  • Molecular Weight 113.12
  • Synonym(s) 1H-1,2,4-Triazole-1-ethanol
  • SMILES OCCN1N=CN=C1

Description

2-(1H-1,2,4-Triazol-1-yl)ethan-1-ol features a polar triazole moiety linked to a hydroxyl-bearing ethylene tether, enabling robust hydrogen bonding and enhanced solubility in aqueous and protic solvents. This combination supports its utility in medicinal chemistry scaffolds and ligand design.

Application

2-(1H-1,2,4-Triazol-1-yl)ethan-1-ol serves as a versatile building block in medicinal chemistry, enabling the introduction of a polar, hydrogen-bond-capable triazolylethanol moiety. Its hydroxyl group facilitates further functionalization via esterification or ether formation, while the 1,2,4-triazole ring provides metabolic stability and enhanced solubility. The compound exhibits good bench stability and is compatible with standard coupling protocols, making it valuable for constructing bioactive heterocyclic scaffolds and fragment libraries.

Synthesis

  • Route1
    • In-stock
      1,2,4-Triazole|CS-D1150
      288-88-0
    • null|null
      107-07-3
    • ~88%
    • In-stock
      2-(1H-1,2,4-Triazol-1-yl)ethan-1-ol|CS-0179616
      3273-14-1

    References

    • Burdeinyi; Popkov; Kharchevnikova Russian Chemical Bulletin, 2009 , vol. 58, # 5 p. 936 - 939
  • Route2
    • In-stock
      1,2,4-Triazole sodium|CS-0136347
      41253-21-8
    • null|null
      107-07-3
    • ~23%
    • In-stock
      2-(1H-1,2,4-Triazol-1-yl)ethan-1-ol|CS-0179616
      3273-14-1

    References

    • Merck Sharp and Dohme Ltd. Patent: US6355798 B1, 2002 ; US 6355798 B1
  • Route3
    • In-stock
      1,2,4-Triazole|CS-D1150
      288-88-0
    • null|null
      96-49-1
    • ~42%
    • In-stock
      2-(1H-1,2,4-Triazol-1-yl)ethan-1-ol|CS-0179616
      3273-14-1

    References

    • Burdeinyi; Popkov; Kharchevnikova Russian Chemical Bulletin, 2009 , vol. 58, # 5 p. 936 - 939

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.94
  • LogP   -0.7296
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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