2-Bromo-3,5-difluorophenol

Name: 2-Bromo-3,5-difluorophenol
Brand: ChemScene
Availability: InStock
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CAS No. 325486-43-9
Cat. No. CS-W015187
Purity≥98%
MDL No.MFCD01861127

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 325486-43-9
Cat. No. CS-W015187
Purity ≥98%
MDL No. MFCD01861127
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃BrF₂O
Molecular Weight 208.99
Synonym(s) QR CF EF BE
SMILES OC1=C(Br)C(F)=CC(F)=C1

Description

2-Bromo-3,5-difluorophenol delivers a trifunctional aromatic scaffold with orthogonal reactivity. The bromine moiety enables cross-coupling transformations, while the para-fluorine and ortho-fluorine substituents enhance electrophilicity and metabolic stability. This bench-stable phenolic building block integrates readily into complex molecular architectures under standard conditions.

Application

2-Bromo-3,5-difluorophenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct Suzuki-Miyaura and Stille coupling reactions due to its halogenated aromatic core. The ortho-bromo functionality facilitates palladium-catalyzed cross-coupling, while the fluorinated ring enhances metabolic stability and modulates electronic properties. Bench-stable and readily purified by recrystallization, it functions efficiently in late-stage functionalization strategies.

Synthesis

Route1
- In-stock
  
  2713-34-0
- ~59%
- In-stock
  
  325486-43-9
References
- Eli Lilly and Company Patent: US7045545 B1, 2006 ; Location in patent: Page/Page column 33 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 20.23
LogP 2.4329
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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2-Bromo-3,5-difluorophenol

CAS No. 325486-43-9

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