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CS-W001157 4
Total: USD 88.00

4-Morpholine acetic acid

  • CAS No. 3235-69-6

  • Cat. No. CS-M2897
  • Purity≥97%
  • MDL No.MFCD00504633

*For research and further manufacturing use only, not for direct human use.

4-Morpholine acetic acid|CS-M2897

Structure of 3235-69-6

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General Information

  • CAS No. 3235-69-6
  • Cat. No. CS-M2897
  • Purity ≥97%
  • MDL No. MFCD00504633
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁NO₃
  • Molecular Weight 145.16
  • Synonym(s) morpholin-4-ylacetic acid
  • SMILES O=C(O)CN1CCOCC1

Application

4-Morpholine acetic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through its amine and carboxylic acid functionalities. Its morpholine ring provides enhanced solubility and metabolic stability, while the α-amino acid backbone facilitates conjugation reactions and peptide-like coupling protocols. The compound exhibits good bench stability and is compatible with standard protection/deprotection strategies, making it suitable for iterative synthesis workflows in API development.

Synthesis

  • Route1

    References

    • ORION CORPORATION; LINNANEN, Tero; WOHLFAHRT, Gerd; NANDURI, Srinivas; UJJINAMATADA, Ravi; RAJAGOPALAN, Srinivasan; MUKHERJEE, Subhendu Patent: WO2013/53983 A1, 2013 ; Location in patent: Page/Page column 40 ;
  • Route2
    • Methyl Morpholinoacetate|CS-0206057
      35855-10-8
    • ~92%
    • In-stock
      4-Morpholine acetic acid|CS-M2897
      3235-69-6

    References

    • ANORMED INC. Patent: WO2006/138350 A2, 2006 ; Location in patent: Page/Page column 76 ; WO 2006/138350 A2
  • Route3
    • Benzyl 2-morpholinoacetate|CS-0453410
      53342-23-7
    • ~95%
    • In-stock
      4-Morpholine acetic acid|CS-M2897
      3235-69-6

    References

    • Kempf, Dale J.; Codacovi, Lynnmarie; Wang, Xiu Chun; Kohlbrenner, William E.; Wideburg, Norman E.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 3 p. 320 - 330

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   -0.5968
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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