Lot numbers can be found on the outside label of a product:
1-tert-Butyl 4-methyl 4-aminopiperidine-1,4-dicarboxylate
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CAS No. 321997-89-1
- Cat. No. CS-0067892
- Purity≥95%
- MDL No.MFCD06200674
*For research and further manufacturing use only, not for direct human use.
Structure of 321997-89-1
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General Information
- CAS No. 321997-89-1
- Cat. No. CS-0067892
- Purity ≥95%
- MDL No. MFCD06200674
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₂H₂₂N₂O₄
- Molecular Weight 258.31
- Synonym(s) Methyl 1-boc-4-aMinopiperidine-4-carboxylate
- SMILES O=C(N1CCC(N)(C(OC)=O)CC1)OC(C)(C)C
Description
This bench-stable piperidine derivative features a tert-butyl-protected amine and methyl ester functionalities, enabling straightforward deprotection and derivatization. The electron-rich nitrogen centers facilitate efficient coupling reactions, making it a robust scaffold for medicinal chemistry libraries and peptide mimetics.
Application
1-tert-Butyl 4-methyl 4-aminopiperidine-1,4-dicarboxylate serves as a versatile building block in medicinal chemistry, enabling the construction of piperidine-based scaffolds common in bioactive molecules. The protected amine and ester functionalities offer orthogonal reactivity, facilitating selective transformations. Bench-stable and readily purified, it functions effectively in standard coupling, alkylation, and cyclization protocols for API development.
Synthesis
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Route1
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In-stock
183673-71-4 -
18107-18-1 - ~73%
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In-stock
321997-89-1
References
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SMITHKLINE BEECHAM PLC Patent: EP1214314 B1, 2005 ; Location in patent: Page/Page column 17 ;
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Route2
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186581-53-3
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In-stock
183673-71-4
- ~%
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In-stock
321997-89-1
References
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WO2005/47253 A1, ; Page/Page column 49 ; WO 2005/047253 A1
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Route3
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98-74-8
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In-stock
183673-71-4
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18107-18-1
- ~%
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In-stock
321997-89-1
References
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US2003/139414 A1, ; US 20030139414 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Quality Control
Computational Chemistry Data
- TPSA 81.86
- LogP 0.8878
- H_Acceptors 5
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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