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CS-W001157 4
Total: USD 88.00

2-(6-Cyanopyridin-2-yl)acetic acid

  • CAS No. 321592-49-8

  • Cat. No. CS-0533095
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(6-Cyanopyridin-2-yl)acetic acid|CS-0533095

Structure of 321592-49-8

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General Information

  • CAS No. 321592-49-8
  • Cat. No. CS-0533095
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆N₂O₂
  • Molecular Weight 162.15
  • Synonym(s) None
  • SMILES N#CC1=CC=CC(CC(O)=O)=N1

Description

This 2-(6-cyanopyridin-2-yl)acetic acid features a pyridine ring bearing a nitrile group at the 6-position, coupled with a carboxylic acid-functionalized ethyl spacer. The electron-deficient pyridine ring enhances reactivity in conjugate addition and transition metal-catalyzed coupling processes. This structure enables integration into bioconjugation scaffolds and pharmaceutical intermediates where polarity and hydrogen-bonding capacity are critical.

Application

2-(6-Cyanopyridin-2-yl)acetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyridine-containing heterocycles and bioactive molecules. Its nitrile and carboxylic acid functionalities offer orthogonal reactivity for derivatization, including amidation, esterification, and nucleophilic substitution. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthetic workflows and scale-up applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   73.98
  • LogP   0.58038
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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